Expert of Antibody Production and Genetic Modification

Better IgG protection

FcRn Overexpression – Better IgG Protection

Figure 1Figure 1

WILD TYPE ANIMALS BFCRN TRANSGENIC ANIMALS
Most antibodies are degraded More antibodies are recycled

 

 

 

FcRn overexpression significantly increases half-lives of mouse and human IgGs

Figure 1Figure 1

Mouse IgG clerance in tg and wt mice Human IgG clearance in tg and wt mice

 

 

Pharmacokinetic analysis of the mouse and human IgGs in bFcRn transgenic (Tg) and wild type (wt) mice. Mean±SEM serum concentrations of injected mouse IgG and human IgG in Tg and wt mice; insert shows the half-life values of injected IgGs (Bender et al. 2007, Transgenic Research).