Better IgG protection
FcRn Overexpression – Better IgG Protection
|WILD TYPE ANIMALS||BFCRN TRANSGENIC ANIMALS|
|Most antibodies are degraded||More antibodies are recycled|
FcRn overexpression significantly increases half-lives of mouse and human IgGs
|Mouse IgG clerance in tg and wt mice||Human IgG clearance in tg and wt mice|
Pharmacokinetic analysis of the mouse and human IgGs in bFcRn transgenic (Tg) and wild type (wt) mice. Mean±SEM serum concentrations of injected mouse IgG and human IgG in Tg and wt mice; insert shows the half-life values of injected IgGs (Bender et al. 2007, Transgenic Research).