Expert of Antibody Production and Genetic Modification

OVERVIEW - Custom Antibody Services (CAS)

Technology

INTRODUCING IMG-ABS™


ImmunoGenes' patented technology platform IMG-AbS™, is an FcRn technology using genetically modified animals that overexpress the neonatal Fc Receptor (FcRn). Because of FcRn's role in antigen presentation, the company's animals are able to mount a strong immune response against weakly immunogenic targets.

Our recent studies have illustrated the advantageous effects of FcRn overexpression to significantly improve humoral immune response in the generation of antibodies, in principle, as biotherapeutics or in diagnostic assays.

IMG-AbS™ technology:

  • Generates antibodies against weakly immunogenic antigens
  • Produces highly diverse antibodies
  • Generates a higher number of antigen specific B cells
  • Breaks immune tolerance to highly conserved antigens
  • Significantly improves hybridoma production
  • Higher levels of circulating antibodies
  • Thus, FcRn transgenesis enjoys a number of practical benefits, including a route to the generation of antibodies against antigens of low immunogenicity that are difficult to address using currently available methods.

 

http://www.immunogenes.com/images/Figure1.jpg

Intellectual Property

The IMG-AbS™ platform is protected by broad patent claims that have already been granted in Europe, Canada, Australia, Hong Kong, China and Japan.

Our patent portfolio has been designed to protect the entire class of antibodies derived from the IMG-AbS™ platform. Each antibody arising from the platform will also be covered by individual composition of matter IP.

We enjoy full freedom to operate under our patent coverage and till date have not granted exclusive licenses for IMG-AbS™ against any therapeutic target.