Expert of Antibody Production and Genetic Modification

Custom Transgenic Services (CTS)

There is a growing demand for pre-clinical testing in specialized animal models to increase predictability for outcome in human clinical trials. The demand for these animal models has also increased recently to satisfy the need for superior models for certain diseases including cardiovascular, pulmonary and ophthalmic indications.

The timely creation of such specialized transgenic animals under high quality standards is limited to a select group of experts – ImmunoGenes being one of them.

Under the leadership of Dr. Zsuzsanna Bosze, ImmunoGenes has built a track record of excellence in the field of transgenic animal creation for a wide range of specialty needs. Dr. Bosze, one of the scientific founders of ImmunoGenes is an authority in the field of Transgenesis

ImmunoGenes' offers a variety of custom transgenic services in a number of different animal models, including rabbits, rats and mice, by microinjecting large genomic fragments at its state-of-the-art facility. The Custom Transgenic Services (CTS) team consists of Dr. Bosze along with a group of leading experts in the field of transgenesis, and collaborates with some of the foremost institutions in this field- including The Roslin Institute of the University of Edinburgh, INRA-France, and PolyGene AG. 

What we offer:
  • Interactive transgene design
  • Rapid turnaround time and efficient world-wide delivery
  • Proven track record with some of the world's leading developers of rabbit and rat models
  • Breeding and genotyping services

Join some of the world's leading biotechnology companies in sourcing your transgenic animal models from ImmunoGenes.

Please contact us to obtain a quote.

Publications

Szebényi K, Füredi A, Kolacsek O, Csohány R, Prókai Á, Kis-Petik K, Szabó A, Bősze Z, Bender B, Tóvári J, Enyedi Á, Orbán TI, Apáti Á, Sarkadi B. 2015. Visualization of Calcium Dynamics in Kidney Proximal Tubules. J Am Soc Nephrol. 2015 Nov; 26(11)2731-40 (Pubmed)

Bender B, Baranyi M, Kerekes A, Bodrogi L, Brands R, Uhrin P, Bösze Z.Recombinant human tissue non-specific alkaline phosphatase successfully counteracts lipopolysaccharide induced sepsis in mice. Physiol Res. 2015;64(5):731-8. (Pubmed)
 
Bender B, Hoffmann OI, Negre D, Kvell K, Bosze Z, Hiripi L. 2013. Low titer lentiviral transgenesis in rodents with simian immundeficiency virus vector. Biotechniques 55: 137-40 (PubMed)

 

Catunda Lemos AP, Cervenak J, Bender B, Hoffmann OI, Baranyi M, Kerekes A, Farkas A, Bosze Z, Hiripi L, Kacskovics I. Characterization of the rabbit neonatal Fc receptor (FcRn) and analyzing the immunophenotype of the transgenic rabbits that overexpress FcR. PLoS One. 2012;7(1):e28869. doi: 10.1371/journal.pone.0028869. Epub 2012 Jan 11. (PubMed)

Duranthon V, Beaujean N, Brunner M, Odening KE, Santos AN, Kacskovics I, Hiripi L, Weinstein EJ, Bősze Z. On the emerging role of rabbit as human disease model and the instrumental role of novel transgenic tools. Transgenic Res. 2012 Aug;21(4):699-713. doi: 10.1007/s11248-012-9599-x. Epub 2012 Mar 2. (PubMed)

Hiripi L, Negre D, Cosset FL, Kvell K, Czompoly T, Baranyi M, Gocza E, Hoffmann O, Bender B, Bosze Z. 2010. Transgenic rabbit production with simian immunodeficiency virus-derived lentiviral vector. Transgenic Res 19: 799-808 (PubMed)