About Us

Benefits of IMG-AbS™

FcRn Overexpression – higher antigen specific immunoglobulin titers and more antigen-specific B-cells

FcRn overexpression results in increased antigen-specific IgM, IgG, and total IgG levels and number of antigen-specific B-cells

A


B

 

A cont

C


B

D


B

Tg and wild-type mice were immunized with ovalbumin (OVA) (A) OVA-specific IgM and (B) OVAspecific IgG titers were nearly tripled in Tg mice compared with the wild-type (wt) animals. (C) Tg mice produced significantly higher amounts of total IgG compared to the wt mice. (D) Larger spleen and multiple-fold increase of OVA-specific IgM and IgG producer cells was detected in Tg mice compared with wt controls (Cervenak et al. 2011. The Journal of Immunology).