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Benefits of IMG-AbS™

FcRn Overexpression – allow production of antibodies against of highly conserved antigens - breaking immune tolerance

Immunization with highly conserved mouse cannabinoid receptor type 1 (CB1; GPCR) resulted in CB1-specific mAbs only in bFcRn Tg mice (C-terminal mouse CB1 specific oligopeptide conjugated to KLH; this segment is identical to its human ortholog)


Mouse Type CB1 Positives Clones (IgG)  
Balb/c 0
bFcRn Tg 10